Question

What is one difference between receptors that are degraded versus receptors that are recycled by the endocytic pathway?
- Only degraded receptors are endocytosed with their cargoes.

- Only degraded receptors are packaged into clathrin-coated vesicles.

- Only degraded receptors are mono-ubiquitinated.

- Only recycled receptors are endocytosed with their cargoes.

Answer 1

In the endocytic pathway The receptor may be recycled to the surface by vesicles that bud from the endosome and then target the plasma membrane. After these recycling vesicles fuse with the plasma membrane, the receptor is returned to the cell surface for further binding and activity. The exact fate of the receptor in the membrane appears to vary with the cell. It can also be degraded. However, some receptors move to the Golgi complex to be added back to membranes in the Trans Golgi region. This would recycle the receptor.
Endocytosis occurs by a variety of mechanisms that can be divided into those that are clathrin-dependent and those that are clathrin-independentIn clathrin-dependent endocytosis (CDE), the cytoplasmic domains of plasma membrane proteins are specifically recognized by adaptor proteins and packaged into clathrin-coated vesicles that are brought into the cell.