Question

What is an advantage of an enzyme with multiple domains each with a different catalytic site.

Answer 1

The contemporary advantages ascribed to multidomain enzymes include (a) the potential for metabolite channeling and the protection of unstable intermediates; (b) the potential for interactions between domains catalyzing sequential steps in a metabolic pathway, thereby giving the potential for allosteric interactions; and (c) the facility to produce enzymic activities in a fixed stoichiometric ratio.

example: glutamine-dependent carbamoyl phosphate synthetase (CPSase)