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1) a. Why is actin treadmilling important for cell migration? b. If you increase the concentration...

1) a. Why is actin treadmilling important for cell migration?

b. If you increase the concentration of extracellular matrix substrate on your tissue culture-treated plates, do you expect the density of focal adhesion in the cells to increase, decrease, or not be affected?

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Answer #1

Actin treadmilling is the phenomenon which drives the actin in motion in eukaryotes. This allows for the formation of filopodia, lamellipodia, and pseudopodia which are "feet" of the cell and is used for cellular locomotion.

On increasing the concentration of extracellular matrix substrate in the tissue culture-treated plates, the density of focal adhesion in the cells will not be affected because cell speed is independent of focal adhesion, surface density and molecular composition.

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