Question

The key difference between biologic and non-biologic DMARDs is that:
i. Biologic DMARDs have single specific targets
ii. Biologic DMARDs are derived from biological extracts
iii. Non-Biologic DMARDs are designed in a laboratory
iv. Non-Biologics affect inorganic targets
v. Non-Biologics affect a rage of targets simultaneously

Select one:

A. i, v

B. i, iii

C. ii, iv

D. ii, v

Answer 1

B. i, iii

Explanation: Biologic DMARDs are target specific. They have single specific target e.g. Infliximab and Abatacep are the TNF-alpha and T- cell inhibitors respectively. Both these Biologic DMARDs are specific to the TNF-alpha and T- cell. Non-Biologic DMARDs are designed in a laboratory by the process of drug designing and synthesis.

Explanation for wrong answers

Biologic DMARDs are not derived from biological extracts they are synthetic small molecules. Non-Biologics affect inorganic targets as well as organic targets. Non-Biologics are not affect a rage of targets simultaneously.