Question

The activity site of ribonucleotide reductase can bind two different molecules, whereas the specificity site can...

The activity site of ribonucleotide reductase can bind two different molecules, whereas the specificity site can bind several. Construct a situation where the activity of the enzyme is inhibited by choosing the identity of the molecules bound to each site.

Homework Answers

Answer #1

The secnario where the enzyme activity is dimnished where the identity of the molecule concerned is a typical case of competitive inhibition.Here the inhibitor closely has structural similarities with the susbtrate and can bind to the active site of the enzyme .This reduces the site availability for substrate and enzyme activity is reduced.

An other way is by allosteric inhibition in which the inhibitor binds to the allosteric site(site other than the active site) and changes the arrangement or the conformation of the active site and hence inhibits the susbstrate binding thereby stopping enzyme activity.

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