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Assume that this amino acid is on the surface of the protein. Would you expect this...

Assume that this amino acid is on the surface of the protein. Would you expect this mutation (alanine mutated to threonine), to have any effect on the three-dimensional shape of the protein? Explain.

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Answer #1

The three-dimensional shape of the protein is dependent on the specific interactions between amino acid residues such as electrostatic interactions, hydrogen bonding, hydrophobic interactions, etc. Since alanine is a non-polar amino acid, while threonine is a polar amino acid it will have an effect on the three-dimensional shape of the protein. However, the quantitative effect is dependent on the surrounding amino acid residues and position of the amino acid.

The alanine residue is on the surface of the protein. So, it can be predicted to not have much effect on the three-dimensional shape of the protein.

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