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19.If the frequency of the sickle cell allele in a particular population is 0.12, what is...

19.If the frequency of the sickle cell allele in a particular population is 0.12, what is the frequency of heterozygotes? What percentage of the population is expected to have sickle cell disease?

20.In the previous problem, I suspect you applied the Hardy-Weinberg equation (if not: GIGANTIC HINT). However, a frequency of the sickle cell allele that high is likely only to exist in a population where malaria is endemic - it’s not expected to be that high elsewhere. Given that information, explain why application of the Hardy-Weinberg equation might not be the appropriate way to calculate the frequency of heterozygotes and homozygotes in this case.

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Answer #1

19.

20. H-W equilibrium states that the allele frequencies tend to remain constant provided there are no mutation, migration, genetic drift or selection.

The presence of the malarial parasite (P. falciparum) in the endemic regions exerts strong selective pressure with respect to (in favor of) the sickle cell allele., creating disturbance in the H-W equilibrium.

Thus, application of the Hardy-Weinberg equation might not be the appropriate way to calculate the frequency of heterozygotes and homozygotes in this case.

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