Question

1) Which ONE of the following is NOT TRUE about PML-RAR: a) the translocation is caused...

1) Which ONE of the following is NOT TRUE about PML-RAR:

a) the translocation is caused by ionizing irradiation and found in Hiroshima and Nagasaki victims

b) it is a fusion protein created by a reciprocal translocation found in acute promyelocytic leukemia

c) the fusion protein retains the ability of the retinoic acid receptor (RAR) to bind retinoic acid and DNA

d) PML contains zinc fingers and a coiled-coil domain, which are important for maintaining the structure of nuclear bodies

2) The CRISPR-Cas9 is a genome editing system. It was first discovered as…

a) The defense mechanism in bacteria against bacteriophages

b) The defense mechanism in bacteria against humans

c) he defense mechanism in zebrafish against bacteria

d) The defense mechanism in bacteria against macrophages

e) The defense mechanism in zebrafish against sharks

3) Which ONE of the following is NOT a method by which a tumor suppressor gene can lead to cancer:

a) incorporation into a retroviral genome

b) none of the answers (i.e., all of the other answers are true)

c) chromosomal deletion of the gene

d) loss of heterozygosity by non disjunction

e) methylation of the promoter of the tumor suppressor gene

4)

DNA Damage and the cell cycle:

Describe the mechanism by which DNA damage such as a double-strand break leads to cell cycle arrest.

Be sure to include:

a) how the pathway is regulated

b) why it is important to regulate the cell cycle during conditions of DNA damage

Homework Answers

Answer #1

1. a) the translocation is caused by ionizing irradation and found in Hiroshima and Nagasaki victims.

2. a) the defence mechanism in bacteria against bacteriophages.

3. b) none of the answers are false

4.

When DNA damages through ionizing radiation, genotoxic chemicals ,it increases the level of P53 protein which determine to arrest the cell cycle in G1 phase.

B) when checkpoint mechanism detect that dna is damaged, cell cycle is halted. Otherwise it will cause cancer.

A) phosporylation is acted by cycline dependent kinase and check points regulate dna damage.

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
QUESTION 10 Which ONE of the following is NOT TRUE about protein kinases: RAS, RAF, PKC,...
QUESTION 10 Which ONE of the following is NOT TRUE about protein kinases: RAS, RAF, PKC, PI3K, CDK and MAPK are all examples of kinases they add phosphate groups to either serine, threonine or tyrosine residues their kinase activity is tightly regulated by regulatory domains or inhibitory proteins they tend to be proto-oncogenes 2 points    QUESTION 11 Which ONE of the following is NOT true about DNA viruses and cancer: HPV E6, HPV E7 and SV40 large T antigen...
Which ONE of the following is NOT TRUE about noncoding RNAs: microRNAs (~22 nucleotides long) regulate...
Which ONE of the following is NOT TRUE about noncoding RNAs: microRNAs (~22 nucleotides long) regulate gene expression via RNA degradation microRNAs regulate genes expression via inhibition of translation microRNAs are encoded as genes in the human genome and can act as either oncogenes or tumor suppressor genes long non coding RNAs (lncRNAs) are 20,000+ nucleotides long QUESTION 2 Which ONE of the following is NOT a method by which a tumor suppressor gene can lead to cancer: incorporation into...
38. which of the following are strategies for combating cancer, with the exception of... a. immunotherapy...
38. which of the following are strategies for combating cancer, with the exception of... a. immunotherapy b. inhibition of cancer promoting proteins c.promoting the formation of new blood cells d. promoting the expression of tumor suppressor genes e. none of these, all are good strategies. 37. which of the following statements is unlikely true? a. secondary malignant tumors often can be removed to eliminate the cancer b. generally benign tumors can be removed and do not grow back c. cells...
Multiple Choice Please answer all 3 no need to go in Depth Which of the following...
Multiple Choice Please answer all 3 no need to go in Depth Which of the following would be most likely to lead to cancer? failure of a proto-oncogene to produce a protein and amplification of a tumor-suppressor gene hyperactivity of both a proto-oncogene and a tumor-suppressor gene failure of both a proto-oncogene and a tumor-suppressor gene to produce proteins amplification of a proto-oncogene and inactivation of a tumor-suppressor gene hyperactivity of a proto-oncogene and activation of a tumor-suppressor gene How...
12.       Which of the following statements regarding integrins is true? A.         they function as a heterodimer of alpha...
12.       Which of the following statements regarding integrins is true? A.         they function as a heterodimer of alpha and beta integrins B.         they utilize adaptor proteins such as beta-catenin to link to the actin cytoskeleton C.        they can bind to more than one type of ECM protein D.        all of the above Answer _________ 13.       The glycoprotein fibronectin has which of the following features: A.         it is calcium dependent B.         it functions as a dimer connected by disulfide bonds C.        it is a glycosaminoglycan D.        all of the above Answer...
3. Which of the following are true of chemotherapeutic agents? Select all that apply. The adverse...
3. Which of the following are true of chemotherapeutic agents? Select all that apply. The adverse side-effects of chemotherapeutics are strongest in cell types that dividing rapidly (hair, blood and GI tract).    They create broken chromosomes or stalled replication forks. These agents are toxic to cancer cells because they are part of a tumor. The cytotoxic effect of these DNA damaging agents requires the cell to be actively dividing. 4.   Which statement below best describes an oncogene? Gene that...
Q1. Which of the following is a sequencing-based technique that can be used to compare the...
Q1. Which of the following is a sequencing-based technique that can be used to compare the change in expression of all of the genes in treated and untreated cells to determine how gene expression changes due to the treatment? a) GWAS b) Gene expression microarray c) RNAseq d) Metagenomics Q2. Which of the following statements is CORRECT? a) The most common site of DNA methylation is the guanine CpG islands. b) Vinclozolin was found to only affect the mice exposed...
QUESTION 46 Which of the following statements is TRUE concerning the function of proto-oncogenes? A. Their...
QUESTION 46 Which of the following statements is TRUE concerning the function of proto-oncogenes? A. Their products are components of cell growth pathways. B. They make products that act as signals to initiate cellular apoptosis. C. Proto-oncogenes make products that scan the genome for DNA damage. D. Proto-oncogenes make products that act as cell checkpoint regulators. E. Proto-oncogenes make products that repair DNA at sites of lesions. QUESTION 51 In which of the following biochemical reactions is it common to...
PLEASE ANSWER THESE QUESTIONS 1.The annotated sequence of the HIV genome allows biologists to identify drugs...
PLEASE ANSWER THESE QUESTIONS 1.The annotated sequence of the HIV genome allows biologists to identify drugs that can interfere with the HIV cycle and prevent infection.  The annotated genome of HIV containing the open reading frame BLANK , which is a gene that encodes protein components of the capsid,BLANK , which encodes proteins needed for reverse transcription and incorporation into the host DNA, and BLANK, which encodes proteins that are embedded in the lipid envelope. 2.In bacteria, the supercoils of DNA...
Multiple choice questions ( questions may have more than one answer ) 1. Which of the...
Multiple choice questions ( questions may have more than one answer ) 1. Which of the following is true for tumor suppressor protein? a. A protein which gives a cell a growth advantage b. A protein which inhibits cell proliferation c. A protein which helps mitosis d. Both alleles have to be inactivated to start carcinogenesis 2. Which of the following statements about forensic analysis of DNA is true? a. A DNA profile using short tandem repeats (microsatellites) is unique...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT