PFK2 gene codes for a protein that is involved in the synthesis and degradation of fructose-2,6-biphosphate. The encoded protein 6-phosphofructo-2-kinase acts as a catalyst in the synthesis of fructose-2,6-biphosphate. The encoded protein fructose-2,6-biphoshatase catalyses degradation of fructose-2,6-biphosphate. The gene encodes proteins that regulate the levels of fructose-2,6-biphosphate in heart. The enzyme phosphofructokinase 2 or fructose biphosphatase 2 regulates the rate of glycolysis and gluconeogenesis.
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