Question

Assume a typical neuron with equilibrium potential for potassium, EK = -80mV and a resting potential of -65mV. How would the resting membrane potential (Vm) of this neuron change if it were immersed in a bath containing a concentration of K+ 20% greater than normal K+ concentration?

Answer 1

Increase in extracellular concentration of K+ would slow the efflux of K+ and increases the infflux of K+ and moving of K+ into the cell causes the depolarisation of the cell. while decreasing extracellular concentration of K+ causes increase in K+ efflux and causes hyperpolarisation of the cell. During depolarisation of the cell, membrane potential become more positive. When the membrane become more negative than resting potential, it is known as hyperpolarization, and when, membrane potential increases from resting potential is known as depolarization.