Question

Analyzing patterns of Mendelian inheritance Harry and Meghan are planning a family. In addition to their love for each other and for humanitarian activism, they have something else in common. They each have a history of cystic fibrosis in their family. Cystic fibrosis (CF) is an autosomal recessive disease. • Meghan, her mother, and two of her three sisters do not have CF. But one of her sisters and her father have CF. • Harry does not have CF, and two of his three brothers don’t either. But he has one brother with CF. Neither of his parents have CF.

Twelve people are mentioned in this scenario (not including Harry and Meghan's child). Identify each individual out of those twelve whose genotype is uncertain (cannot be determined with complete certainty) in light of the given information above

Answer 1

Ans- from the above information we got that out of 12 people 3 are having CF. So there are 9 people whose genotype is uncertain. Now harry have one brother with CF but his parents don't have CF so they both must be carrier, so they came in category of known genotype.

Now we left with 7 person out of 12 whose genotype is uncertain.from the above information we can only conclude the genotype of 5 people out of 12 so the genotype of remaining 7 people remain uncertain from the provided information.