Question

Gastric acid (select the BEST CORRECT statement)

		Pepsinogen autocatalyzes the enzymatic cleavage of an inhibitory 44 amino acid peptide, a reaction that is optimal in the high pH environment of the stomach lumen.
		Endocrine cells of the duodenum release secretin, a peptide hormone that causes endocrine cells of the pancreas to secrete bicarbonate.
		A drug that inhibits the H+/K+-ATPase pump on the surface of gastric parietal cells would also indirectly inhibit the activity of pepsin.
		All of the above are correct
		Only (a) and (b) are correct

Answer 1

All the above are correct

Pepsinogen is pre enzyme or zymogen form of pepsin which are secreted and than the extra 44 amino acids can be clevaed at acidic environment of the stomach by auto cleavage mechanism. Endocrine cells of deodenum in small intestine secretes secretin which activates pancreatic cells to secrete bicoebonate

When H+ pumb is inhibited by the inhibitors present on the gastric parietal cells, the pH of the lumen becomes less acidic so that pepsin cannot be cleaved and become active form thus indeirectly inhibits pepsin