Question

Mutations in the gene encoding PTEN are found in a large number of human cancers. These...

Mutations in the gene encoding PTEN are found in a large number of human cancers. These mutations typically

Increase the levels of PTEN.
Increase the activity of PTEN
Decrease levels of PTEN
A & B.
None of the above.
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Answer #1

Ans. PTEN gene acts as a tumor suppressor gene. A functional copy of PTEN gene encodes PTEN protein that prevents the expression of oncogenes.

However, the mutated PTEN gene does NOT express or produce a functional copy of the PTEN protein. The lack or reduced expression of PTEN protein leads to activation of some oncogenes and onset of cancer.

So, correct option is- C. Decreased levels of PTEN (protein).

# Option A, B. Incorrect. Mutated PTEN gene does not encode a functional PTEN protein. So, mutation in PTEN gene always leads to REDUCED or LOWER levels of PTEN protein. A lower PTEN protein level in turn exhibits lower activity.   

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