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Fructose-1,6-bisphosphatase and phosphofructokinase (PFK-1) are inversely regulated by ____ and _____. a. fructose-2,6-bisphosphate; AMP b. insulin-glucagon...

Fructose-1,6-bisphosphatase and phosphofructokinase (PFK-1) are inversely regulated by ____ and _____.

a. fructose-2,6-bisphosphate; AMP

b. insulin-glucagon ratio

c. feedback inhibition; phosphorylation/dephosphorylation

d. A and B

e. B and C

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Answer #1

E is the answer

Fructose 1, 6 biphosphatase is the key regulator of gluconeogenesis and convert Fructose 1,6 biphosphate to Fructose 6 phosphate. Insulin inhibits gluconeogenesis so the action of Fructose 1 6 biphosphatase is inhibited. Phosphofructokinase is the key regulator of glycolysis and it does the opposite of Fructose 1 6 biphosphatase, that is it converts Fructose 6 phosphate to Fructose 1 6 biphosphate. Glycolysis is inhibited by glucagon so this enzyme is inhibited by glucagon.

Fructose 1,6 biphosphatase is inhibited by AMP. Increased AMP level indicates that ATP level is low so rather than gluconeogenesis, Glycolysis will undergo.

Phosphorylation inhibit fructose 1 6 biphosphatase. Phosphorylation is undertaken by kinase. Dephosphorylation inhibit phosphofructokinase. Dephosphorylation is undertaken by phosphatase.

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