Question

11. Balanced translocations are those that evenly exchange genetic material between 2 nonhomologous chromosomes with no loss in genetic material. The individuals that have balanced translocations can be phenotypically normal, but they can have a greater risk of producing gametes with unbalanced combinations of chromosomes. Why is that? Draw a diagram of all potential gametes to support your answer.

12. For the following template strand of DNA, transcribe and translate it into a peptide. You must show the mRNA and the peptide using the single letter abbreviation for the amino acids.

5’ – TTAATCCTCGTGGCTAATGTTGATGAAACTGGTGATGTCTGCTAGGCCCATGATGTACAT – 3’

Answer 1

11. Individuals who are translocation carriers are phenotypically normal because they have at least one copy of each of the translocated chromosomes. But the fertility is reduced drastically because of the formation of gametes with monosomy and trisomy.

Below is an example if translocation occurs between chromosome number 13 and 14 -

12.

mRNA,

5' UUA AUC CUC GUG GGC UAA UGU GAU GAA ACU GGU GAU GUC UGC UAG GCC CAU GAU GUA CAU 3'

Amino acids,

N - L I L V G - C

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