A person with type A blood receiving a transfusion of type B would have an ABO incompatibility reaction. In an ABO incompatibility reaction, the immune system attacks the new blood cells and destroys them. When it comes to Rh compatibility, anyone who is Rh positive can receive blood from someone who is Rh-negative. This transfusion will not work. It will cause a severe reaction that may be life-threatening, the immune system attacks the new blood cells and destroys them.
Though the person with type AB blood can get transfusions of B red blood cells. People with Rh-negative blood can get Rh-negative red blood cells. So this transfusion would work safely.
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