Question

Please define which neurotransmitter is associated with each network:

● Nigrostriatal pathway ● Mesolimbic pathway ● Mesocortical pathway ● Locus coeruleus

Answer 1

1.Nigrostriatal pathway - Dopamine.

The nigrostriatal pathway is the dopaminergic pathway which connects substantia nigra pars compacta with caudate nucleus and putamen.

2.Mesocortical pathway- Dopamine

It is also a dopaminergic connection existing between the ventral tegmental area in the mid brain and the cerebral cortex. It forms an extensive connection with the frontal lobe.

3.Mesolimbic pathway- Dopamine

This pathway connects the ventral tegmental area to nucleus accumbens and olfactory tubercle. It is also called the reward pathway.

4.Locus coeruleus -Norepinephrine

Its major site of norepinephrine synthesis in the brain. The locus coeruleus is a nucleus found in the pons. It is a part reticular activating system.