Question

A. If 1/10000 has an autosomal recessive disease in a given population, what is the estimated...

A. If 1/10000 has an autosomal recessive disease in a given population, what is the estimated carrier frequency of the mutant allele?

B. If a disorder is genetic lethal, what is its fitness?

*if anyone can help me with this, I would greatly appreciate it. I'm new to genetics =(

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Hardy and Weinberg described all the possible genotypes for a gene with two alleles. The binomial expansion representing this is, p2 + 2pq + q2 = 1.0

Where,

p2 = proportion of homozygous dominant individuals

q2 = proportion of homozygous recessive individuals

2pq = proportion of heterozygotes (carries one recessive and one dominant allele)

a). Given that, the frequency of autosomal recessive disease in a population is, q2 = 1/10000

The frequency of q = 1/100 or 0.01

Assuming that the population is in H-W equilibrium, the frequency of dominant allele, p = 1-0.01 = 0.99

The frequency of carriers is = 2pq = 2*0.99*0.01 = 0.0198 or 198/10000

B). If a genetic disease is lethal, it reduces the fitness of an allele (associated with the disease)

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Consider a single-gene disease that has an autosomal recessive pattern of inheritance in humans. Assume that...
Consider a single-gene disease that has an autosomal recessive pattern of inheritance in humans. Assume that the disease-causing gene is in Hardy-Weinberg equilibrium within a population. Suppose that the disease affects 0.17% of the population. (A)What is the frequency of the normal allele in the population? (B)What is the frequency of the mutated (diseased) allele in the population? (C)What percent of the population is an unaffected carrier of the disease?
Neurofibromatosis is an autosomal dominant disease. The frequency of the recessive allele is 0.98. In population...
Neurofibromatosis is an autosomal dominant disease. The frequency of the recessive allele is 0.98. In population of 2250 how many individuals would you expect to not have the disease?
A boy is born with an autosomal recessive genetic disease that is determined by a single-gene...
A boy is born with an autosomal recessive genetic disease that is determined by a single-gene defect. Both his parents are unaffected. What is the most accurate statement can we say about the parents genotypes with respect to the relevant locus? In the following statement there are 2 fill in spots, i am providing the options given at these spots and putting them in bold, and in parentheses. (ONE/BOTH) of his parents must be ["homozygous", "heterozygous"] for the disease-causing allele
5. Tay-Sach disease is due to an autosomal recessive allele t. The disease results in death...
5. Tay-Sach disease is due to an autosomal recessive allele t. The disease results in death of tt individuals before reproductive age. The relative fitnesses of the genotypes are TT=1, Tt=1, tt=0. a. What type of selection is occurring on this locus, and what do you expect will happen to the f(t) over time? b. Explain in general terms how Mutation-Selection Balance can keep the t allele in the population at a constant (equilibrium) frequency.
Cystic fibrosis (CF) is an autosomal recessive disease. In a South American country, a study was...
Cystic fibrosis (CF) is an autosomal recessive disease. In a South American country, a study was conducted to test the hypothesis that cystic fibrosis carriers were less likely to be affected and die from by tuberculosis (TB) infection. To begin the quantitative study, researchers needed to identify the number of individuals in the population that were carriers, knowing the frequency of the cystic fibrosis allele was 0.1 in the population. After their analysis, the researchers concluded that there was evidence...
Cystic fibrosis is a disease caused by a recessive allele.  If 12% of the population has cystic...
Cystic fibrosis is a disease caused by a recessive allele.  If 12% of the population has cystic fibrosis, then what is the frequency of individuals who are heterozygous for the gene that causes cystic fibrosis in the population? 0.35 0.65 0.12 0.46
question 14 part 1 Tay-Sachs disease is lethal disorder caused by a recessive mutation, in this...
question 14 part 1 Tay-Sachs disease is lethal disorder caused by a recessive mutation, in this case at the TS locus in humans. TS/TS and TS/ts genotypes do not show symptoms of the disease; however, by the age of 6 months, ts/ts infants begin to regress, usually dying by the age of five. No cure is known for Tay-Sachs. Tay-Sachs most commonly strikes people from relatively small, closed societies, specifically those of eastern European Jewish (Ashkenazy Jews) and Louisiana (US)...
In human genomes, the per nucleotide mutation rate is estimated to be about 2.5 x 10^-8....
In human genomes, the per nucleotide mutation rate is estimated to be about 2.5 x 10^-8. Let us consider a recessive lethal genetic disease caused by a single point mutation. We will name the allele produced by this point mutation L, and the wild-type allele W. Let us further assume that the disease phenotype expressed by LL individuals always kills those who have it before they reproduce. What would you predict the equilibrium frequency of the allele L be in...
Part II – Genetic Basis of the Disorder As Alexander’s family and you have now discovered,...
Part II – Genetic Basis of the Disorder As Alexander’s family and you have now discovered, spondyloepiphyseal dysplasia congenita (SEDC) is a genetic disorder in which the primary deficits are abnormal growth of one or more spinal vertebrae and the growing ends of the femurs, resulting in disproportionate, short-trunk dwarfism (Parikh & Crawford, 2017). Interestingly, both of Alexander’s parents, his grandparents and an older sister are of normal height. Therefore, what do you think the mode of inheritance is for...
The picture shown below shows variation among three individuals with respect to 4 nucleotides - AGAT....
The picture shown below shows variation among three individuals with respect to 4 nucleotides - AGAT. What do you think what type of variation is this? AGAT different repeat numbers in different individuals .png Minisatellite Single nucleotide polymorphism Short Tandem Repeats Which of the following statements is TRUE about DNA matching? Typical difference between the genomes of human beings and Chimpanzees is estimated to be 25 % Typical difference between the genomes of human beings and Drosophila is   estimated to...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT