Question

Identify the CORRECT statement about the metabolismof 2-deoxy-2-[18F]-fluoro-D-glucose (also known as FDG) by tumour cells.

a. it enters tumour cells but is not metabolized

b. it enters tumour cells, is converted to FDG-6-phosphte by hexokinase but is not further metabolized

c. it enters tumour cells, and is converted to fluoro-deoxyfructose-1,6-bisphosphate but is not further metabolized

d. it enters tumour cells and is metabolized by glycolysis to give 18F-pyruvate

e. it enters tumour cells and is completely oxidized by a combination of glycolysis, pyruvate dehydrogenase and the Krebs Cycle

Answer 1

FDG enters the tumor cells and gets phosphorhylated to FDG-6-Phosphate.but doesnot get further metabolised in the glycolytic pathway and remain interacellularly in the cell

Tumor cells doesnot contain sufficient of glucose 6 phosphatase to reverse the phosphorhylation.

Increased glycolytic activity and glucose transport in the tumor cells increases uptake of FDG into the cells.

Hence, option B is correct.

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