Question

Which statement is a prediction of the multifactorial threshold liability model?

a) An individual's risk is not altered by the number of affected first-degree relatives.

b) Affected individuals almost always have an affected parent.

c) The differential risk to relatives of affected proband increases with the severity of the deformation or disease

d) Recurrence risks are the same for different families with the same disease

e) The differential risk to relatives of an affected proband increases along with the disease prevalence

Answer 1

The correct answer is : The differential risk to relatives of an affected proband increases along with the disease prevalence

The predictions of the multifactorial threshold liability model states that :

• Recurrence risks represent average risks and can vary among different families.
• The danger increases with the quantity of affected relatives.
• The danger increases with the severity of the malformation or disease.
• The differential risk to relatives of an affected proband increases because the frequency of the disease or malformation within the population decreases.