Question

Which heterophilic and inducible cell-surface receptors play roles in leukocyte extravasation through an endothelium? a. Cadherins...

Which heterophilic and inducible cell-surface receptors play roles in
leukocyte extravasation through an endothelium?
a. Cadherins on the blood cell, connexons on the endothelium
b. Integrins on the blood cell, selectins on the endothelium
c. Cadherins on the blood cell, selectins on the endothelium

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Answer #1

Answer :

Leucocyte extravasation from vessels to site of inflammation is a multistep process. Proteins on surface of blood cells and endothelium of vessels take part in this process.

Selectins are group of cell adhesion glycoproteins. Important role in relation of circulating cells and endothelium. E and P selectins are of particular importance.

Integrins are expressed exclusively on WBC. Integrins are also adhesion molecules.

These helps rolling leucocytes bind to endothelium.

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