Question

Explain the mechanism of how a single nucleotide base change in a gene can lead to...


Explain the mechanism of how a single nucleotide base change in a gene can lead to premature termination of translation of the mRNA from that gene.

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

This type mutation causing a single nucleotide change to prematurely stops the translation and results in a truncated protien is called as non-sense mutation.

A nonsense mutation is the substitution of a single base pair that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid. The mutation results in coding for stop codon which interupts the translation and ends in a truncated protien. (Image source:NIH)

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Genetics:Pick a specific tumor suppressor gene or oncogene and explain how this gene can lead to...
Genetics:Pick a specific tumor suppressor gene or oncogene and explain how this gene can lead to or prevent cancer. Be sure to focus on the mechanism of how your chosen gene impacts the cell cycle. You can alternatively pick a virus that has been associated with cancer and explain how that virus impacts the cell cycle and ultimately leads to cancer. In laymen's terms please, this is a litlle confusing to me, thank you
Acridine dyes such as proflavin are known to induce primarily single base-pair additions and deletions. Suppose...
Acridine dyes such as proflavin are known to induce primarily single base-pair additions and deletions. Suppose that the wild-type nucleotide sequence in the mRNA produced from a gene is 5'-AUGCCCUUUGGGAAAGGGUUUCCCUAA-3' Also, assume that a mutation is induced within this gene by proflavin and, subsequently, a revertant of this mutation is similarly induced with proflavin and shown to result from a second-site suppressor mutation within the same gene. If the amino acid sequence of the polypeptide encoded by this gene in...
The cytosine nucleotide base of the dCpG dinucleotide DNA sequence in the human tumor suppressor gene,...
The cytosine nucleotide base of the dCpG dinucleotide DNA sequence in the human tumor suppressor gene, TP53, has been changed to dTpG by a mutation. Which of the following type of mutations is referred to this base change? (d=deoxy;p=phosphodiester bond; C=cytosine; G=Guanine;T=Thymine) Tranversion Deletion Transition
Explain why the carbocation intermediate mechanism can lead to the syn and/or anti addition product, but...
Explain why the carbocation intermediate mechanism can lead to the syn and/or anti addition product, but the bromonium ion mechanism can only lead to anti addition product
1.       Define proto-oncogene and tumor suppressor gene. Compare and contrast the function and mechanism of action of...
1.       Define proto-oncogene and tumor suppressor gene. Compare and contrast the function and mechanism of action of these genes taking Ras and Rb as examples. 2.       What is the difference between maternal inheritance and X-linkage? Give specific examples. 3.       Define ‘single nucleotide polymorphism’.  How can SNPs be useful in genetics? 4.       Why do eukaryotic genes have introns? What are spliceosomes? What is alternative splicing? 5.       Give the definition of a promoter. Are the elements found in the proximal promoter and distal promoter regions the same for...
Identify which of the factors listed below is a mechanism by which bacterial cells can regulate...
Identify which of the factors listed below is a mechanism by which bacterial cells can regulate the abundance of a specific protein in the cell. Select all that apply. Group of answer choices Control DNA polymerase activity Recruit the appropriate sigma factor to the core RNAP complex Stabilize a protein through protease activity Degrade DNA with a specific promoter sequence Alter the termination of mRNA synthesis Modify the supercoiled state of the DNA around a gene
Explain how the change in a monetary variable could lead to a change in the real...
Explain how the change in a monetary variable could lead to a change in the real GDP in the LM-IS equilibrium?
Explain the mechanism of allosteric regulation and provide examples how this mechanism can be used to...
Explain the mechanism of allosteric regulation and provide examples how this mechanism can be used to tune the flow of molecules in a metabolic pathway.
Select a single most appropriate statement in the following questions. Each question is worth two marks....
Select a single most appropriate statement in the following questions. Each question is worth two marks. Q1 Transcription from a mutated gene gets aborted only after synthesis of 10 or 15 bases long mRNAs. If the sequence of the 10 base mRNA is 3`-AUGCUAGCGG-5`; the sequence of 15 base mRNA transcribed by this mutated gene will be a. 5`-GGCGAUCGUA AUGGG-3` b. 5`-AUGGG GGCGAUCGUA -3` c. 5`-AUGCUAGCGG AUGGG-3` d. 5`-AUGGG AUGCUAGCGG -3` e. 5`-UACGAUCGCC AUGGG-3` Q2 In transcription, the Rho protein...
The Central Dogma Explain how our genes control our traits with a specific example. Your explanation...
The Central Dogma Explain how our genes control our traits with a specific example. Your explanation should contain the following words: transcription, translation, gene, mRNA, and protein. You should include the name of a specific gene and a specific protein, and try explain how the role of that particular protein relates to the trait (example: the pigment melanin is a protein that results in brown eyes, skin and hair). To demonstrate that you have understood how transcription and translation works,...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT