The carbon skeletons for gluconeogenesis are derived from:
a. Amino acids from the degradation of skeletal muscle protein
b. Glycerol from the breakdown of triglycerides in adipose tissue
c. Oxidation of fatty acids to acetyl CoA
d. A and B
e. A, B, and C
Answer: d. A and B
I.e. Both amino acid from the degradation of skeletal muscle protein and glycerol from the breakdown of triglycerides in adipose tissue can be as carbon skeletal for gluconeogenesis.
Oxidation of fatty acid will lead to the formation of Acetyl-CoA will may enter into TCA cycle but will be used and released in the form of carbon dioxide.
Glycerol can be used after converting itself into glycerol-6-phosphate with the help of glycerol kinase.
Mostly alanine and glutamine is used in the gluconeogenesis. Transamination or destination helps them in entering gluconeogenesis cycle.
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