Question

A student says" gluconeogenesis is just reverse of glycolysis" Do you agree or disagree with this statement. why? explain!

Answer 1

Answer:

Gluconeogenesis is not exactly the reverse of the glycolysis process. There are two types of reversible and irreversible steps occur in the glycolysis process. Reversible steps are similar in both process but irreversible steps are different.

Glycolysis is the sequence of reactions that metabolizes one molecule of glucose to two molecules of pyruvate and ATP. It is an anaerobic reaction. It is in next step to lactic acid or ethanol. but in aerobic reaction pyruvate can be completely oxidized to CO2.

In Gluconeogenesis it is synthesized through non-carbohydrate precursor-like glucogenic amino acid. There are following three irreversible reactions in Gluconeogenesis different from glycolysis.

1.Conversion of Pyruvate to PEP

2. Dephosphorylation of fructose

3.Dephosphorylation of glucose 6-phosphate