1) Mitochondrial DNA is
a) maternally inherited
b) paternally inherited
c) responsible for multiple sclerosis
d) 10 times less likely to mutate than nuclear DNA
2) All of the following statements about the enzymic complex that carries out the synthesis of ATP during oxidative phosphorylation are correct EXCEPT:
A. It is located on the matrix side of the inner mitochondrial membrane.
B. It is inhibited by oligomycin.
C. It contains a proton channel.
D. It can exhibit ATPase activity.
E. It can bind molecular oxygen.
3) Which of the statements below about the ATP synthase complex is FALSE?.
a) The F 0 complex of ATP synthase contains the channel for the return of protons to the matrix.
b) The F 1 section of ATP synthase consists of a center subunit (gamma) and three surrounding protein subunits, which have three active sites with different shapes or conformations known as loose (L), tight (T), and open (0).
c) As protons flow through the F 0 channel of ATP synthase, energy released turns the center subunit (gamma ) like a river that turns a water wheel.
d) As the center unit supplies energy to the three active sites, their shapes change.
e) none of the above
4) Which of these statements are FALSE about the glycerol phosphate shuttle?
A The glycerol phosphate shuttle is a simple, very efficient shuttle that involves substrate transport.
B In this process, glycerol-3-phosphate carries electrons from NADH made in glycolysis from the cytosol across the inner mitochondrial membrane.
C The glycerol phosphate shuttle is a means for transporting NADH produced in glycolysis to the mitochondria at the ETC to be regenerated to NAD+
D Under aerobic conditions, extramitochondrial NADH does not accumulate and is presumed to be oxidized by the respiratory chain in mitochondria.
E This process involves transfer of reducing equivalents through the mitochondrial membrane via substrate pairs, linked by suitable hydrogenases.
5) Which of these statements are FALSE about the glycerol phosphate shuttle?
In the glycerol phosphate shuttle
A- The NAD+ is actually regenerated in the cytosol by the Glycerol-3-P DH reaction, which reduces dihydroxyacetone-P to glycerol-3-P
B- Electrons are transferred from NADH to dihydroxyacetone phosphate in the formation of glycerol 3-phosphate.
C- Glycerol-3-P is reoxidised to dihydroxyacetone-P by Flavoprotein dehydrogenase; an enzyme that is situated on exposed on the outer surface of the inner mitochondrial membrane.
D Of the two glycerol-3-phosphate dehydrogenase involved in this shuttle, the cytosolic version has FAD+ as one of its' substrates, whereas the mitochondrial form of the enzyme has rate, NADH as one of its' substrates.
1.The mitochondrial DNA is always maternally inherited because the spern cells cytoplasm lacks mitochondria when it fuses with the female cytoplasm.So the progeny will always has the mitochondrial inherited from maternal side.So mitochondria will show maternal inheritance.So answer a is right.
2.The answer is E that it can bind to molecular oxygen.
3The correct answer is b which is about the description of gamma subunit.
4.The answer is b as the NADH is carried to inner mitochondrual membrane and not electrons .
5.The correct answer is d.
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