Question

What is the fate of a target mRNA that is bound by a RISC complex and...

What is the fate of a target mRNA that is bound by a RISC complex and miRNA that is perfectly comlementary with the mRNA target (with no mismatches)?

A.

The target mRNA is cleaved so that no protein is made from the transcript.
B.

The ribosome stalls and cannot synthesize a protein.
C.

The target mRNA is cleaved but proteins can still be made.
D.

The ribosome stalls but makes protein after it recovers.
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Answer #1

Option A,

Once the microRNA (miRNA) molecules are incorporated in the multi-protein RNA-Induced Silencing Complex (RISC) while interacting with their target mRNA, they are capable of suppressing the gene expression through various mechanisms. Generally, they bind to the 3'-UTR i.e the un-translated region of their target mRNAs to destabilize them. A destabilized mRNA does not undergo translational silencing and hence the process of protein production is repressed.

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