Question

B cells traffic between the light and dark zones in the germinal center to acquire high affinity antibodies. What is the importance of the interaction between the B and Tfh cells in the light zone? a. It allows B cell to re-enter into the dark zone.

b. It allows B cell to bind tighter to the antigen.

c.It signals the formation of primary B cell follicle.

d.All of the above.

Answer 1

The right option is option (B) It allows B cell to bind tighter to the antigen

Explanation:-

T follicle cells secrete cytokines which induces the proliferation of B cells into mature B cells which can either produce antibodies or become memory B cells. B cells upon receiving signals from Follicular T cells, they undergoes selection and only those which have higher affinity for the antigens are selected. These selected cells then can go clonal expansion.

T follicular cells do not signals the formation of B cell follicle