Question

1. True or False : Several oncogenes encode antiapoptotic proteins that promote cell survival

2. True or False: Cancer Patients with mutant p53 can be treated effectively with radiation therapy

3. Tumor promoter is a type of carcinogen that

a. decreases chromosomal stability

b. increases cell proliferation

c. induces apoptosis of healthy cells

d. immortalizes cancer cells

4. Tumor initiation occurs in a

a. single cell

b. few cells

c. single protein molecule

d. single tissue

5. True or False: Transformation can be assayed in crll culture

Answer 1

Answer 1- false

Reason- because protooncogenes like BCL-2 is the main antiapoptotic gene that promotes cell survival.

Answer 2- false

Reason:- The response to chemotherapy and radiation, t most cancer cells harboring p53 mutations show a reduced sensitivity compared to cells lacking p53.

Answer 3- d) immortalizes cancer cells

Reason- they help the tumor cells to survive and expand in number and grow unlimitedely

Answer 4- a) single cell

Reason- tumor initiation, is the result of a genetic alteration leading to abnormal proliferation of a single cell.

Answer 5-true

Reason- Transformation can be assayed in cell culture