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Describe the cellular location, main components and main function of this complex. can u tell me...

Describe the cellular location, main components and main function of this complex.

can u tell me please

question is based on cellular bioenergetics

it's dehydrogenase complex

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Answer #1

ANS-function-Dehydrogenase complex is a multi subunit protein that oxidises pyruvate to acetate in the form of acetyl CoA this reaction is called as oxidative decarboxylation .

Presence-It is present in mitochondria because oxidation of pyruvate is taking place there, the reaction is

pyruvate +NAD++CoA give rise to Acetyl CoA + NADH+CO2

structure -pyruvate dehydrogenase component E1 - 30 subunits each is having thiamine pyrophosphate .It catalyse decarboxylation and oxidation on pyruvate to hydroxyethyl group

Dihydroliopyl transacetylase E2-transfer acteyl group to coenzyme A

Dihydroliopyl dehydrogenase E3-catalyse the regeneration of oxidized form of li[oamide with concomitant reduction of NAD+ to NADH

its function can be inhibited by high concentration of NADH,phosphorylation of E1 component ,increase in ca2+ concentration.

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