Question

Describe the role and specific changes of the nuclear lamin (intermediate filament proteins) at interphase, prophase, telophase.

Answer 1

In Interphase the nuclear lamin exist as a polymerized form containing A and B lamins. The initiation of mitosis in the cells involves the disassembly of the cellular components.

At Prophase the nuclear lamiina are thus disassembled. The disassembly initiated by Cyclin B/Cdk1 protein kinase (Maturation promoting Factor). This phosphorylation of cyclin B causes the depolymerization of lamins, where B type lamins are associated with fragments and A type fragments are solublized for the whole process of mitosis.

During the telophase nuclear reassembly occurs where the nuclear lamin are imported into cells via the novel nuclear pore complex using the Nuclear localization Signal.