Question

p53 is protein coded by a gene located in chromosome 17. It plays a crucial role...

p53 is protein coded by a gene located in chromosome 17. It plays a crucial role in preventing cancer formation. Explain briefly how p53 can block cancer formation.

type your qustion.

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

How p53 can block cancer formation :

p53 is a tumor suppressor protein that can block the cancer formation by inducing DNA repair gene.

When DNA damage occurs in a cell then p53 is accumulated into the cell. It induces DNA repair gene , WAF1. This gene is translated to form p21 protein. This p21 is a regulatory protein that binds with CDK4-CyclinD complex and inactivate them. So the cell is arrested in G1 phase. G1 to S progression is blocked.

P53 also plays a key role in apoptosis that lead to block cancer formation. When excessive DNA damage occurs then p53 does not induce DNA repair gene. It induce the pro apoptotic gene such as Bak, Bax, bid etc. The proteins from such genes help in apoptotic pathway of the cell. Thus the cancer formation is blocked.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Question text In drosophila (fruit flies): The yellow gene is on the X-chromosome, the gene product...
Question text In drosophila (fruit flies): The yellow gene is on the X-chromosome, the gene product plays a role in body colour. Wild type flies are a light brown/tan in colour, homozygote yellow mutants have a more yellow shaded body colour. We'll use y+ to represent the wild type allele, and y to represent the mutant allele. y+ is dominant to y. The vestigial gene is on chromosome 2. Homozygote vestigial mutants have very short wings, and cannot fly. We'll...
3. A receptor protein (RPX) has been shown to be involved in mediating transcription of gene...
3. A receptor protein (RPX) has been shown to be involved in mediating transcription of gene X. RPX has a binding region for metabolite (M). In the absence of metabolite, acetylase p300 is recruited to form a complex involved in chromatin remodelling. In the presence of metabolite, deacetylase HDAC1 is recruited to form a complex involved in chromatin remodelling. A) In the absence of metabolite, how would you characterize the role (one word) of RPX regarding transcription? Briefly explain your...
In Drosophila, the gene for white (w) eyes is on the X chromosome and it is...
In Drosophila, the gene for white (w) eyes is on the X chromosome and it is epistatic over brown and scarlet. White eyes can also result by crossing brown-eyed females (bw) with scarlet eyed males (st) (that is, when both mutant alleles are present). A cross is made between white-eyed females with the genotype w//w (otherwise, homozygous for wild type alleles) and white-eyed males hemizygous for the wild type allele (w+ ). List the expected: a) Genotypes of the P1...
In Drosophila, the gene for white (w) eyes is on the X chromosome and it is...
In Drosophila, the gene for white (w) eyes is on the X chromosome and it is epistatic over brown and scarlet. White eyes can also result by crossing brown-eyed females (bw) with scarlet eyed males (st) (that is, when both mutant alleles are present).A cross is made between white-eyed females with the genotype w//w (otherwise, homozygous for wild type alleles) and white-eyed males hemizygous for the wild type allele (w+ ). List the expected: a) Genotypes of the P1 and...
QUESTION 10 Which ONE of the following is NOT TRUE about protein kinases: RAS, RAF, PKC,...
QUESTION 10 Which ONE of the following is NOT TRUE about protein kinases: RAS, RAF, PKC, PI3K, CDK and MAPK are all examples of kinases they add phosphate groups to either serine, threonine or tyrosine residues their kinase activity is tightly regulated by regulatory domains or inhibitory proteins they tend to be proto-oncogenes 2 points    QUESTION 11 Which ONE of the following is NOT true about DNA viruses and cancer: HPV E6, HPV E7 and SV40 large T antigen...
Please answer all questions if you can. Thank you in advanced! 1. Compare and contrast how...
Please answer all questions if you can. Thank you in advanced! 1. Compare and contrast how secondary structure forms in folded proteins and folded RNA molecules 2. Assume that a bacterial genome contains 5000 genes. Do a “back of the envelope” calculation to estimate the size (number of nucleotides) of the genome of this bacterium. In your answer briefly demonstrate your knowledge of genes. 3. Describe the design of the DNA sequence of an artificial chromosome in a typical eukaryote...
I post this question twice, please don't answer this post if you already answer the other...
I post this question twice, please don't answer this post if you already answer the other one, if you can answer different answer that's fine. REASON WHY I POST IT TWICE, I NEED TWO DIFFERENT VIEW. Discussion Hi All - this week you will learn about DNA - the molecule of life! You may think that protein-coding genes are the most important, but results from the Human Genome Project revealed that only about 2% of our DNA codes for protein...
The picture shown below shows variation among three individuals with respect to 4 nucleotides - AGAT....
The picture shown below shows variation among three individuals with respect to 4 nucleotides - AGAT. What do you think what type of variation is this? AGAT different repeat numbers in different individuals .png Minisatellite Single nucleotide polymorphism Short Tandem Repeats Which of the following statements is TRUE about DNA matching? Typical difference between the genomes of human beings and Chimpanzees is estimated to be 25 % Typical difference between the genomes of human beings and Drosophila is   estimated to...
9. Depression, hot flashes and cessation of the menstrual cycle are typical symptoms of _______.            a....
9. Depression, hot flashes and cessation of the menstrual cycle are typical symptoms of _______.            a. PMS b. Menopause c. Infertility d. ovarian cancer              10. A standard screening test for cervical cancer is called _______.                    Pap Smear       Genome sequencing ELISA NAAT testing              11. The actual gene sequence governing the expression of a trait is called a _______. a. Phenotype b. Genotype    c. Haplotype d. Molecular signature 12. The physical expression of this trait is the _______, which...
ANSWER ALL QUESTIONS FOR GOOD RATING :) QUESTION 13 A mating between a male donkey and...
ANSWER ALL QUESTIONS FOR GOOD RATING :) QUESTION 13 A mating between a male donkey and a female horse results in a mule, but the reciprocal mating leads to a phenotypically different hybrid, named hinny. The reason for the phenotypic difference between mules and hinnies is due to The different number of chromosomes in the hinny and the mule The differential sex-specific methylation of the DNA in the gametes of the horse and the donkey The presence of plasmid DNA...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT