Question

From a strictly mechanistic point of view (i.e., ignoring practicalities, FDA approval, etc), what drugs might be most appropriate for a breast cancer patient with the following known mutations? Explain with signaling diagrams.

(c) KRAS (d) ERBB1

Answer 1

Ans. People with inherited BRCA mutations who have metastatic breast cancer should be offered platinum chemotherapy ,if possible . Drug that may be used for metastatic breast cancer include : capecitabine (xeloda) carboplantin ( available as genetic drug ) ,tucatinib.

KRAS SIGNALLING:

ERBB1 signalling: