Question

Cellular respiration is regulated by stimulating or inhibiting the enzyme phosphofructokinase which catalyzes one reaction in...

  1. Cellular respiration is regulated by stimulating or inhibiting the enzyme phosphofructokinase which catalyzes one reaction in glycolysis. If a cell has an excess of ATP available how does this affect phosphofructokinase activity? Describe why it is important for cells to regulate cellular respiration.
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Answer #1

In the case of hIgh ATP, the activity curve shifts right which represents that the phosphofructokinase enzyme activity becomes slower and requires higher concentration of Fructose-6-phosphate for converting it to Fructose-1,6-bisphosphate.

The importance of regulation of cellular respiration:

The molecules that bind cellular respiration enzymes act as signals, giving the enzyme information about the cell's energy state. ATP, ADP, and NADH are examples of molecules that regulate cellular respiration enzymes. ATP, for instance, is a "stop" signal: high levels mean that the cell has enough ATP and does not need to make more through cellular respiration. This is a case of feedback inhibition, in which a product "feeds back" to shut down its pathway.

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