Question

List the following events in the order that they occur during cancer metastasis: 1. Tumor cells...

List the following events in the order that they occur during cancer metastasis:

1. Tumor cells migrate through the ECM in the connective tissue compartment.

2. Tumor cells enter the bloodstream and establish a new tumor.

3. Additional mutations within the tumor cells allows degradation of the basement membrane.

4. Benign tumor cells grow in a primary tumor.

A. 2, 4, 1, 3

B. 4, 3, 1, 2

C. 2, 3, 1, 4

D. 4, 1, 2, 3

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