This is an essential cofactor for pyruvate dehydrogenase complex and whose deficiency results in this disease.
A. |
Vitamin B1, Beriberi |
|
B. |
Vitamin B12, Anemia |
|
C. |
Vitamin C , Scurvy |
|
D. |
Biotin, No deficiency noted |
|
E. |
None of the above |
What high energy intermediate in glycolysis is generated by Enolase?
a. |
None of the above |
|
b. |
1,3-Bisphosphoglycerate |
|
c. |
Fructose-1,6-Bisphosphate |
|
d. |
2-Phosphoglycerate |
|
e. |
Phosphoenolpyruvate |
Ans:
A. Vitamin B1, beriberi
Explanation: The essential cofactor of pyruvate dehydrogenase complex are thyamine pyrophosphate, NAD+, FAD, CoA and lipoic acid. Thyamine pyrophosphate is a derivatives of vitamin B1 and play important role as a cofactor in the oxidative decarboxylation of -keto acids. Beriberi is the major B1 deficiency syndrome. cobalamin is the derivatives of vitamin B12 and ascorbic acid is the derivatives of vitamin C. Biotin is a cofactor in carboxylation reaction.
e. Phosphoenol pyruvate.
Explanation: Phosphoenol pyruvate (PEP) is produced from 2-phosphoglycerate in the presence of the enzyme enolase. 2-phosphoglycerate is produced by the enzyme phosphoglyceromutase from 3-phosphoglycerate. 1,3 bisphosphoglycerate is formed by the enzyme glyceraldehyde-3-phosphate dehydrogenase and fructose-1,6- bisphosphate is formed by phosphofructokinase.
Get Answers For Free
Most questions answered within 1 hours.