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Caffeine affects many parts of the body. One thing caffeine does is stop the breakdown of...

Caffeine affects many parts of the body. One thing caffeine does is stop the breakdown of cAMP. Caffeine also allosterically effects enzymes. A) How does caffeine affect glycogen phosphorylase, and B) based on those effect(s), what is the most likely outcome for the activity of glycogen phosphorylase?

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A) caffeine stops the breakdown of cAMP so levels of cAMP in the cell remains high, cAMP activates protein kinase A (PKA) if the concentration of cAMP is high in the cell, the PKA remains active. PKA phosphorylates phosphorylase kinase and activates it, activated phosphorylase kinase phosphorylates glycogen phosphorylase b so that it is converted to glycogen phosphorylase a.

B) Caffeine activates glycogen phosphorylase, that is, increases the activity of glycogen phosphorylase.

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