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What is the net ATP gain or loss when going from the appropriate number of glucose...

What is the net ATP gain or loss when going from the appropriate number of glucose molecules to a C28 fatty acid? Consider all NAD(P)/NAD(P)H and FAD/FADH2 in terms of the total ATP gained or lost?

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Answer #1

Number of carbon atoms = 28
Number of beta oxidation cycles = (28/2)-1 = 13
Number of Acetyl CoA produced = 28/2 = 14
Number of NADH produced = 14
Number of FADH2 produced = 14

1 Acetyl CoA produces 3 NADH, 1 FADH2, and 1 ATP via the TCA cycle.
14 Acetyl CoA = 42 NADH, 14 FADH2, and 14 ATP
1 NADH = 2.5 ATP
1 FADH2 = 1.5 ATP
1 Acetyl CoA = 10 ATP

Total ATP production:
14 Acetyl CoA = 140 ATP
14 NADH = 35 ATP
14 FADH2 = 21 ATP
Total = 196 ATP
Activation = -2 ATP
Net gain = 194 ATP

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