Question

Induction of the late phase of LTP involves:

	A.	recycling of the retrograde transmitters
	B.	inhibition of adenylate cyclase
	C.	cross-linking and internalization of the NMDA receptors
	D.	activation of the CREB transcription factor.
	E.	reduced expression of AMPA receptors

Answer 1

Solution: Induction of the late phase of LTP involves cross linking and interlization of the NMDA receptors. Long term potentiation (LTP) can be elicited by activating N-methyl-D-aspertate (NMDA) type glutamate receptors. The late phase LTP is correlated with some type of long term memory. NMDA receptor dependent LTP may constitute cellular substrates of learning and memory. The early phase of expression of LTP are mediated by AMPA (amino methyl propionic acid) type glutamate receptors.