The genotyping chip produces more false positive results than false negatives, despite having a very high specificity (true negative rate) but a low sensitivity (true positive rate). Can you explain why this finding seems counter-intuitive? Hint: think about how these rates are calculated. (3 marks, 4-6 sentences max)
Genotyping: the process by which the genetic makeup of an individual is compared to a refrence genetic make up taken from some other healthy individual to find out the difference between both the individuals.Genotyping chips are majorly used to detect single nucleotide polymorphism (SNP).
The more rare the genes of an individual are the more less accurate will be the genotyping chip. This is the reason hy it gives more false positive results which are unaccurate and unreliable.
The chances of true positive results decline with declining frequency of alleles. The accuracy of genotyping chips are measure by next generation sequencing data.
These chips are cheap and affordable but are highly not reliable in cases of rare genetic disorders.
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