Question

1. In chapter 2, you learned that a polypeptide in solution usually folds spontaneously into its...

1. In chapter 2, you learned that a polypeptide in solution usually folds spontaneously into its proper three-dimensional shape. The driving force for this folding is the tendency to achieve the most favored thermodynamic conformation. A folded polypeptide can be induced to unfold (i.e. will undergo denaturation) if the solution is heated or made acidic or alkaline. The denatured polypeptide is a random structure, with many possible conformations.

a. What is the sign of ∆G for the folding process? What about for the unfolding (denaturation) process? How do you know?

b. What is the sign for ∆S for the folding process? What about for the unfolding (denaturation) process? How do you know?

c. Will the contribution of ∆S to the free energy change be positive or negative?

d. What are the main kinds of bonds and interactions that must be broken or disrupted if a folded polypeptide is to be unfolded? Why do heat and extremes of pH cause unfolding?

Homework Answers

Answer #1

Answer:

Please rate my answer.................. Thank u......

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions