Question

Draw the mechanism of signaling mediated by receptor tyrosine kinases.

Draw the mechanism of signaling mediated by receptor tyrosine kinases.

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

​​​

Signaling enzymes: protein kinases, Protein phosphatases, lipid kinases, Phospholipases and GTPase activating protein. With SH2 domain they are associated with RTK and the enzymes are turned on directly or indirectly as a consequence of this association. The enzymes can be activated by:

  • Translocation to the membrane which place them near to their substrate.
  • Conformation change in the catalytic domain resulting a change in catalytic activity.
  • Directly by the phosphorylation.
0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
The phosphorylated tyrosine residues on activated receptor tyrosine kinases (RTKs) act as scaffolding sites to bring...
The phosphorylated tyrosine residues on activated receptor tyrosine kinases (RTKs) act as scaffolding sites to bring together downstream signaling proteins. What do you think would be the advantage(s) of bringing proteins of the same signaling pathway in close physical proximity to each other?
What are receptor tyrosine kinases? Discuss and provide an example.
What are receptor tyrosine kinases? Discuss and provide an example.
Be able to draw, in detail, the mechanism of signaling in the following examples: -epinephrine signaling...
Be able to draw, in detail, the mechanism of signaling in the following examples: -epinephrine signaling through the beta-adrenergic receptor, including desensitization. -activation of protein kinase C.
Receptor tyrosine kinase signaling is important for photoreceptor development in the fly eye. When signaling is...
Receptor tyrosine kinase signaling is important for photoreceptor development in the fly eye. When signaling is normal, the R7 photoreceptor develops normally. When signaling is impaired, no R7 cell is made. a) You isolate mutations that prevent dimerization of the receptor. What happens to the fly eye in these mutants? b) You next isolate a second mutation in the same fly that activates Raf. What happens to the fly eye in flies that have both of these mutations?
Which of the following is NOT a common mechanism for termination of receptor signaling? hydrolysis of...
Which of the following is NOT a common mechanism for termination of receptor signaling? hydrolysis of second messengers translational control of the receptor mRNA receptor phosphorylation and desensitization increasing the GTPase activity of the heterotrimeric G protein
Tyrosine kinases catalyze chemical transformations of tyrosine amino acid residues. What is the typical nucleotide cofactor...
Tyrosine kinases catalyze chemical transformations of tyrosine amino acid residues. What is the typical nucleotide cofactor used by the kinase to perform this reaction? Draw the tyrosine structure before and after this reaction, showing proper stereochemistry. Which family of enzymes restores the original tyrosine structure?
1- Nonreceptor tyrosine kinases are: Select one: a. Transmembrane receptors b. Membrane proteins with no enzymatic...
1- Nonreceptor tyrosine kinases are: Select one: a. Transmembrane receptors b. Membrane proteins with no enzymatic activity c. Enzymes that phosphorylate serine and threonine residues d. Peripheral membrane enzymes that associate with receptors e. Inhibitors of transmembrane receptors 2- Which of the following statements about MAP kinase pathways is FALSE? Select one: a. MAP kinases phosphorylate serine and threonine residues b. MAP kinases can be activated by tyrosine kinases c. MAP kinases are present in all eukaryotic cells d. MAP...
Binding of a signaling molecule to which type of receptor leads directly to a change in...
Binding of a signaling molecule to which type of receptor leads directly to a change in distribution of ions on opposite sides of the membrane?    receptor tyrosine kinase.    phosphorylated receptor tyrosine kinase dimer.    ion channel receptor.    G protein-coupled receptor.
When ligands such as growth factors bind to receptor tyrosine kinase (RTKs), they may regulate cellular...
When ligands such as growth factors bind to receptor tyrosine kinase (RTKs), they may regulate cellular proliferation by activating Select one: a. Cyclin dependent kinases (CDKs) b. Beta/gamma subunits of G-proteins c. GDP d. Transcription factors e. Alpha subunits of G-proteins
Which of the following does NOT occur when a receptor tyrosine kinase binds its ligand? a....
Which of the following does NOT occur when a receptor tyrosine kinase binds its ligand? a. Activation of Ras. b. Dimerization of the receptor. c. Cross-phosphorylation of the receptor subunits. d. Activation of heterotrimeric G proteins. Which of the following is FALSE? a. Cells use constitutive secretion to deliver new membrane with its integral membrane proteins to the surface of the cell (plasma membrane). b. Archaeal DNA is located in the nucleus. c. Serine-Threonine kinases phosphorylate (add a phosphate to)...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT