Question

Suppose that the researchers discovered that OFC and DLPFC patients have comparable P3 responses. First describe the pattern of results that Dynamic filtering theory would normally predict in this experiment, and then explain whether these hypothetical results would fit with that prediction. (neuroscience class qn)

Answer 1

Dynamic filtering theory suggests that the orbitofrontal cortex is involved in the selection and active inhibition of neural circuits associated with emotional responses.

Prediction which is true is : a) Event related potentials (ER) were recorded in response to mildly somatosensory and auditory stimuli .Patient with orbitofrontal lesson exhibited enhanced P3 amplitudes(ERP) sa compared to control subjects . b) The results were specific to OFC damage ,since patients with dorsolateral prefrontal cortex did not exhibit enhanced P3 amplitudes

c) These findings suggest that damage to orbitolateral cortex impairs the ability to modulate or inhibit neural responses to aversive stimuli.