Question

Using your knowledge of the main types of non-covalent interactions that occur in biological chemistry, discuss the spontaneous assembly of the four main types of biological structure with stable structures: DNA, proteins, glycans (such as cellulose and chitin) and cell membranes. COMPARE and CONTRAST the various structures in terms of the forces and chemical structures driving their assembly. Finally, DISCUSS why their particular molecular structures allow them to perform their biological roles.

Answer 1

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Molecule	Non-covalent interaction
DNA	Hydrogen bonds
Protein	Hydrogen bonds, Hydrophobic bonds, ionic bonds and van der waals forces
Glycans	Hydrogen bonds and van der waals
Cell membranes	Hydrophobic interactions

To perform their normal functions, these molecules have to be in their native conformation. To maintain their native conformation, apart from covalent bonds, these non- covalent bonds are also important. For proper folding of proteins all these forces are important.