Question

Gene X encodes protein X, which normally functions as a transcription factor, regulating the expression of certain genes. A particular mutant allele of gene X is created by a frameshift mutation. The protein encoded by this mutant allele has kinase activity, meaning it acts as an enzyme that phosphorylates other proteins. This mutation is an example of

A. a loss-of-function mutation.

B. a gain-of-function mutation.

C. a neomorphic mutation.

A and C

B and C

Answer 1

Option B&C-a gain-of-function mutation & Neomorphic mutation.

Here Frame shift Mutation leads to Mutant allele that codes for a protein that has kinase activity, [acts as an enzyme that phosphorylates other proteins]

Loss of Function Mutation:Mutation in which the gene product have no activity or less activity.This is wrong as The new gene codes for protein that have Kinase activity.

Gain of Function Mutation:In this type of Mutation,The gene product have a new Activity or Increase in activity.Here the new Protein got a Kinase activity [Ability to Phosphorylate other proteins]so here it is Gain of function Mutation.

Neormorphic mutation:Here mutation leads to Proteins with Novel molecular function.Here the Mutation caused the gene to have a atypical function of Kinase activity,(gene function that is different from the normal function.)So it is an example of Neomorphsim too.