Question

Which of the following mechanisms in a liver cell contribute to ketoacidosis in type I diabetics?...

Which of the following mechanisms in a liver cell contribute to ketoacidosis in type I diabetics?
1)Increased citric acid cycle activity leading to decreased levels of oxaloacetate

2)Decrease in insulin inhibition of fatty acid oxidation

3)All of the mechanisms contribute to ketoacidosis

4)Reduction in the rate of β-oxidation reactions

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Answer #1

Mechanism that liver cells contribute to ketoacidosis type1 diabetes is - increased citric acid cycle activity by decreased levels of oxaloacetate, as because acetyl- coA produced by beta oxidation enters into the citric acid cycle. In the liver oxaloacetate partially or wholly decreased to form malate in the gluconeogenic pathway and followed by formation of ketone bodies which is released by the liver into the blood. No other tissues can divert / decreased the oxaloacetate in gluconeogenic pathway the way liver cell does. Option 1 is correct.

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