56. You’ve uncovered two genetic immunodeficiency diseases (A and B) that are caused by malfunctioning leukocytes. Leukocytes from diseased individuals are unable to perform their normal function of hunting down and engulfing invading bacteria. To determine how these two diseases affect leukocyte function, you decide to examine their chemotactic abilities towards bacteria (speed and directionality) and their PIP3 production in response to bacteria. Define "speed" and "directionality".
How are the phenotypes of the two diseases the same?
How are the phenotypes of the two diseases different?
Propose a biochemical defect (mutated gene) that would cause the phenotypes associated with Disease A.
Propose a biochemical defect (mutated gene) that would cause the phenotypes associated with Disease B.
Answer-1 The speed is the rate at which the bacteria will move in temperature gradient and directionally means if the direction of the movement after applying a temperature gradient.
Answer-2 The two phenotype are same in the manner that they both affect leucocytes activity.
Answer-3 the both phenotype are different in a manner that they both affect the leucocytes activity with a different mode of action.
Answer-4 The first disease will be due to mutation in MHC gene it will unable the representation of the foreign cell to leucocytes and hence there will be no activity in response to foreign cells or bacteria.
Answer-5 the second mutation will be in bone marrow which produce mutated leucocytes which were unable to make their peroxisome and lysosomes enzymes. This make them unable to kill the foreign cells and bacteria
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