Defects in which cell type are commonly associated with increased cancer risk?
A) B cells B) NK cells C) Macrophages D) T cells
Answer:- B) NK cells
Natural killer (NK) cells are lymphocytes has ability to kill
tumor cells without deliberate immunization or activation.
on activation, NK cells release cytokines and chemokines that
induce inflammatory responses; modulate monocyte, dendritic cells,
and granulocyte growth and differentiation; and influence
subsequent adaptive immune responses.
Natural killer cell deficiency (NKD) is a primary immunodeficiency in which main defect lies in CD56+CD3 natural killer (NK) cells which mediate cytotoxicity against tumors.
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