Question

A hybrid protein resulting from the fusion of two chromosomes (chromosome 22 and chromosome 9) following...

A hybrid protein resulting from the fusion of two chromosomes (chromosome 22 and chromosome 9) following a translocation can result in this type of cancer

Question 30

1)

 Chronic Myeloid Leukemia

2)

 Lung Cancer

3)

 Breast Cancer

4)

 Familial adenomatous polyposis (FAP)

5)

 Hereditary nonpolyposis colon cancer (HNPCC)
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Answer #1

A hybrid protein resulting from the fusion of two chromosomes (chromosome 22 and chromosome 9) following a translocation can result in this type of cancer.

Answer: 1) Chronic Myeloid Leukemia.

This is commonly termed Philadelphia chromosome as it was first discovered in Philadelphia in the 1960s.

In this, two chromosomes, one from 9 and another from 22, In this reciprocal translocation occurs in which two genes fuse one is ABL1 on the 9th chromosome and BCR on 22nd chromosome.

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