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Describe the metabolic consequences of low 5-phosphoribosyl-α-pyrophosphate levels. Answer does not have to be long but...

Describe the metabolic consequences of low 5-phosphoribosyl-α-pyrophosphate levels. Answer does not have to be long but does need to be thorough.

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Answer #1

5-phosphoribosyl-α-pyrophosphate (PRPP) is a pentose phosphate formed by ribose-5-phosphate by enzyme ribose phosphate diphosphokinase.

it is involved in any important reaction or biosynthesis like purine, pyrimidine, Amino acids tryptophan and histidine, cofactor NAD & NADP etc.

Increased levels of PRPP causes overproduction of uric acids leading to gout. the level of PRPP is low in post mitotic cells when the synthesis of nucleotide and DNA is slow.

the low level of PRPP is used up during the treatment of tumours and rapidly dividing cells as the growth of tumours are suppressed due to deficiency of purine and pyrimidine levels.

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