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1) Ran GTPase A) Why is Ran-GTP concentrated in the nucleus? why is Ran-GDP concentrated in...


1) Ran GTPase
A) Why is Ran-GTP concentrated in the nucleus? why is Ran-GDP concentrated in the cytoplasm
B) explain how the concentrating gradients of Ran-GTP and Ran-GDP ensure unidirectional transport of proteins into the nucleus
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Answer #1

a) Ran GTP is concnetrated in the nucleus because of the presence of GTP exchanging factor (GEF) inside the nucleaus wherease Ran-GDP is concentrated in the cytoplasm because of the presence of GTPase which hydrolyzes GTP associated with Ran into GDP.

b) Ran-GDP in the associated with importin and protein with nucleus localization signal and transports (imports) it into the nucleus,when in inside the nucleus Ran-GDP is converted Ran-GTP through GEF which leads to dissociation from importin and protien. in the nucleus Ran-GTP associates with exportin and Protein with NES, export signal and exports. In the cytoplasm this complex is dirupted when Ran-GTP is hydrolyzed into RanGDP

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